Cisplatin and kidney injury

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August undefined, 2024

WebMar 27, 2024 · Cisplatin-induced acute kidney injury (AKI) is common during preoperative chemotherapy for esophageal cancer. The purpose of this study was to investigate the association between AKI after preoperative chemotherapy and postoperative complications in patients with esophageal cancer. Methods WebA known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates …

Mitigation of acute kidney injury by cell-cycle inhibitors that ... - PNAS

WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebThe primary objective was to determine the clinical benefit of mannitol combined with hydration in terms of preventing cisplatin-induced acute kidney injury. The secondary end point was incidence of estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m 2 at 7 days after receiving cisplatin between the two groups. fly tying bobbin rest

Potential Therapeutic Targets for Cisplatin-Induced …

WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. Here, we report that Ehmt2-encoded histone ... WebDec 2, 2024 · It is well recognized that cisplatin may induce acute kidney injury (AKI) during chemotherapy. However, recent work further indicates that cisplatin treatment may have long-term effects in kidneys resulting in the development or progression of chronic kidney disease (CKD) in treated patients ( 16 ). WebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various … green push up bra

Mechanisms of Cisplatin-Induced Acute Kidney Injury ... - PubMed

Neferine mitigates cisplatin-induced acute kidney injury in mice …

WebNov 3, 2024 · The kidney injury caused by cisplatin can present in a variety of ways. As it was clearly proved in some researches, the most serious and common damage induced by cisplatin is acute kidney injury (AKI) which occurs in 20–30% of patients, following a single injection of cisplatin [ 4 ]. WebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [29 ... . Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLoS ONE 2024, ... green pus coming out of fingerWebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … fly tying bobbin holder

"WebMay 8, 2024 · Interindividual variability in kidney injury associated with cisplatin is greater than that explained by pharmacokinetic differences among patients. 2 What, if anything, … " - Cisplatin and kidney injury

Cisplatin and kidney injury

Caught in the crossfire: cancer, cisplatin therapy, and kidney injury ...

WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. WebApr 25, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often …

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WebDec 12, 2024 · Cell Death & Disease - PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells Skip to main content … WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well …

WebOct 15, 2024 · Cisplatin administration for acute kidney injury (AKI) leads to serious side effects and there is a higher risk of death [2]. In clinical practice, the main causes of AKI are infections, nephrotoxic drugs, diabetes, hypertension, sepsis and cardiovascular disease. WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe …

WebMar 27, 2024 · Cisplatin-induced acute kidney injury (AKI) is common during preoperative chemotherapy for esophageal cancer. The purpose of this study was to investigate the … WebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. In this study, IS reduced the expression of Mas receptor ...

WebMar 20, 2024 · The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the incidence and risk factors for CIA development, and if CIA is a useful predictor of long-term renal dysfunction after cisplatin treatment. Methods

WebApr 11, 2024 · NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury. Nature Metabolism - Doke et al. show that NMN and … fly tying bobbinWebOct 22, 2024 · Dose-dependent progression to CKD by repeated cisplatin administration. In order to evaluate the kidney injury after repeated injection of different doses of cisplatin in vivo, male wild type mice ... green push button phoneWebApr 12, 2024 · Surgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective … fly tying booksWebApr 6, 2015 · Acute kidney injury (AKI) is a potentially fatal syndrome characterized by a rapid decline in kidney function caused by ischemic or toxic injury to renal tubular cells. The widely used chemotherapy drug cisplatin accumulates preferentially in the renal tubular cells and is a frequent cause of drug-induced AKI. fly tying books for freeWebNov 1, 2024 · Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of... green push button door releaseWebDec 3, 2024 · In a new paper accepted for publication in the Journal of the American Society of Nephrology, researchers at Yale School of Medicine share findings that indicate that, for the first time, there is a potential renal targeted treatment for kidney injury caused by cisplatin, a widely used anti-cancer drug. green push button coverWebTY - JOUR. T1 - Caught in the crossfire. T2 - cancer, cisplatin therapy, and kidney injury. AU - Humphreys, Benjamin D. PY - 2024/4/1. Y1 - 2024/4/1 green pus out of pimple