Nettet7. mar. 2024 · Here, we describe the identification and characterization of INCB086550, a novel, oral, small-molecule PD-L1 inhibitor. In vitro, INCB086550 selectively and … NettetINCB086550 New Data Sheet For research use only. Not for human use. Cat. No. :BCP40998 CAS No. :2378608-10-5 Purity:98% Get Quotation Now Bulk Inquiry Tel: 0086-13720134139 or [email protected] Chemical Properties&Biological Activity Quality Control&Technical Support Batch: Data Sheet
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http://www.bcpchemlab.com/2378608-10-5-BCP40998-cn NettetINCB086550 (INCB 086550) is a potent, selective small-molecule inhibitor of PD-L1, inhibits PD-L1/PD-1 interaction with IC50 of 3.1, 4.9 and 1.9 nM for human, cynomolgus and rat PD-L1 in HTRF-based assays. INCB086550 inhibited binding of phycoerythrin (PE)-labeled PD-1 (PD-1/PE) to cell surface PD-L1 with IC50 of 13 nM. NettetINCB 086550;INCB-086550; Formula: C41H39N7O4: M. Wt: 693.81: Biological Activity; Description: PD-L1 inhibitor INCB086550 specifically targets PD-L1 expressed on … mlb wife